UnivTrevesV1, Main, Exploration, bibRecord, 001986

Latanoprost eye drops increase concentration of Glycosaminoglycans in posterior rabbit sciera

Identifieur interne : 001986 ( Main/Exploration ); précédent : 001985; suivant : 001987

Latanoprost eye drops increase concentration of Glycosaminoglycans in posterior rabbit sciera

Auteurs : Klaus Trier [Danemark] ; S Ren Munk Ribel-Madsen [Danemark]

Source :

Journal of ocular pharmacology and therapeutics [ 1080-7683 ] ; 2004.

RBID : Pascal:04-0603065

Descripteurs français

Pascal (Inist)
- Latanoprost, Antiglaucomateux, Collyre, Augmentation, Concentration, Glycosaminoglycane, Postérieur, Animal, Lapin, Oeil, Oculaire, Tissu, Sclérotique, Pression, Médicament, Modulation, Intracellulaire, Support matriciel, Corps ciliaire.
Wicri :
- topic : Lapin, Médicament.

English descriptors

KwdEn :
- Animal, Animals, Antiglaucomatous agent, Ciliary body, Concentration, Cornea (drug effects), Cornea (metabolism), Drug, Eye, Eye drop, Female, Glycosaminoglycan, Glycosaminoglycans (metabolism), Increase, Instillation, Drug, Intracellular, Latanoprost, Matrix system, Modulation, Ocular, Ophthalmic Solutions, Posterior, Pressure, Prostaglandins F, Synthetic (administration & dosage), Prostaglandins F, Synthetic (pharmacokinetics), Prostaglandins F, Synthetic (pharmacology), Rabbit, Rabbits, Sclera, Sclera (drug effects), Sclera (metabolism), Spectrophotometry, Tissue, Uronic Acids (analysis).
MESH :
- chemical , administration & dosage : Prostaglandins F, Synthetic.
- chemical , analysis : Uronic Acids.
- chemical , metabolism : Glycosaminoglycans.
- drug effects : Cornea, Sclera.
- metabolism : Cornea, Sclera.
- chemical , pharmacokinetics : Prostaglandins F, Synthetic.
- chemical , pharmacology : Prostaglandins F, Synthetic.
- Animals, Female, Instillation, Drug, Ophthalmic Solutions, Rabbits, Spectrophotometry.

Abstract

Purpose: Glycosaminoglycans are important components of ocular tissues such as the sclera. The pressure reducing effect of a new antiglaucoma drug, latanoprost, is based on an increase in the uveo-scleral outflow by way of modulation of the intracellular matrix of the ciliary body. The purpose of the study was to test the effect of latanoprost on the content of glycosaminoglycans in rabbit cornea and sclera. Methods: Twelve rabbits were studied. Six rabbits were treated for 12 weeks with latanoprost eye drops and 6 with hydroxypropylmethylcellulose, dextran 70 eye drops for control. Samples were taken from cornea and anterior, lateral, and posterior sclera. Glycosaminoglycans were determined quantitatively by spectrophotometry (uronic acids). Results: A significant increase in the concentration of uronic acids was found in all three localisations of sclera from latanoprost-treated animals. The increase was 26%, 24%, and 20% in anterior, lateral, and posterior sclera, respectively. Conclusions: Long-term treatment with latanoprost induces biochemical changes in sclera. The results indicate that topically applied latanoprost reaches the posterior parts of the rabbit eye.

Affiliations:

Danemark

Le document en format XML

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<author><name sortKey="Trier, Klaus" sort="Trier, Klaus" uniqKey="Trier K" first="Klaus" last="Trier">Klaus Trier</name>
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<author><name sortKey="Ribel Madsen, S Ren Munk" sort="Ribel Madsen, S Ren Munk" uniqKey="Ribel Madsen S" first="S Ren Munk" last="Ribel-Madsen">S Ren Munk Ribel-Madsen</name>
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<author><name sortKey="Ribel Madsen, S Ren Munk" sort="Ribel Madsen, S Ren Munk" uniqKey="Ribel Madsen S" first="S Ren Munk" last="Ribel-Madsen">S Ren Munk Ribel-Madsen</name>
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<series><title level="j" type="main">Journal of ocular pharmacology and therapeutics</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animal</term>
<term>Animals</term>
<term>Antiglaucomatous agent</term>
<term>Ciliary body</term>
<term>Concentration</term>
<term>Cornea (drug effects)</term>
<term>Cornea (metabolism)</term>
<term>Drug</term>
<term>Eye</term>
<term>Eye drop</term>
<term>Female</term>
<term>Glycosaminoglycan</term>
<term>Glycosaminoglycans (metabolism)</term>
<term>Increase</term>
<term>Instillation, Drug</term>
<term>Intracellular</term>
<term>Latanoprost</term>
<term>Matrix system</term>
<term>Modulation</term>
<term>Ocular</term>
<term>Ophthalmic Solutions</term>
<term>Posterior</term>
<term>Pressure</term>
<term>Prostaglandins F, Synthetic (administration & dosage)</term>
<term>Prostaglandins F, Synthetic (pharmacokinetics)</term>
<term>Prostaglandins F, Synthetic (pharmacology)</term>
<term>Rabbit</term>
<term>Rabbits</term>
<term>Sclera</term>
<term>Sclera (drug effects)</term>
<term>Sclera (metabolism)</term>
<term>Spectrophotometry</term>
<term>Tissue</term>
<term>Uronic Acids (analysis)</term>
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<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Prostaglandins F, Synthetic</term>
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<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Glycosaminoglycans</term>
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<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cornea</term>
<term>Sclera</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Cornea</term>
<term>Sclera</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Prostaglandins F, Synthetic</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Prostaglandins F, Synthetic</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Female</term>
<term>Instillation, Drug</term>
<term>Ophthalmic Solutions</term>
<term>Rabbits</term>
<term>Spectrophotometry</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Latanoprost</term>
<term>Antiglaucomateux</term>
<term>Collyre</term>
<term>Augmentation</term>
<term>Concentration</term>
<term>Glycosaminoglycane</term>
<term>Postérieur</term>
<term>Animal</term>
<term>Lapin</term>
<term>Oeil</term>
<term>Oculaire</term>
<term>Tissu</term>
<term>Sclérotique</term>
<term>Pression</term>
<term>Médicament</term>
<term>Modulation</term>
<term>Intracellulaire</term>
<term>Support matriciel</term>
<term>Corps ciliaire</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Lapin</term>
<term>Médicament</term>
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<front><div type="abstract" xml:lang="en">Purpose: Glycosaminoglycans are important components of ocular tissues such as the sclera. The pressure reducing effect of a new antiglaucoma drug, latanoprost, is based on an increase in the uveo-scleral outflow by way of modulation of the intracellular matrix of the ciliary body. The purpose of the study was to test the effect of latanoprost on the content of glycosaminoglycans in rabbit cornea and sclera. Methods: Twelve rabbits were studied. Six rabbits were treated for 12 weeks with latanoprost eye drops and 6 with hydroxypropylmethylcellulose, dextran 70 eye drops for control. Samples were taken from cornea and anterior, lateral, and posterior sclera. Glycosaminoglycans were determined quantitatively by spectrophotometry (uronic acids). Results: A significant increase in the concentration of uronic acids was found in all three localisations of sclera from latanoprost-treated animals. The increase was 26%, 24%, and 20% in anterior, lateral, and posterior sclera, respectively. Conclusions: Long-term treatment with latanoprost induces biochemical changes in sclera. The results indicate that topically applied latanoprost reaches the posterior parts of the rabbit eye.</div>
</front>
</TEI>
<affiliations><list><country><li>Danemark</li>
</country>
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<tree><country name="Danemark"><noRegion><name sortKey="Trier, Klaus" sort="Trier, Klaus" uniqKey="Trier K" first="Klaus" last="Trier">Klaus Trier</name>
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<name sortKey="Ribel Madsen, S Ren Munk" sort="Ribel Madsen, S Ren Munk" uniqKey="Ribel Madsen S" first="S Ren Munk" last="Ribel-Madsen">S Ren Munk Ribel-Madsen</name>
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Latanoprost eye drops increase concentration of Glycosaminoglycans in posterior rabbit sciera

Latanoprost eye drops increase concentration of Glycosaminoglycans in posterior rabbit sciera

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

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